RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-433
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
immunofluorescence; PCR; etc.
Target
AZIN1;JNK1
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Crucial Role of miR-433 in Regulating Cardiac Fibrosis
Year
2016
Function
"Forced expression of miR-433 in neonatal rat cardiac fibroblasts increased proliferation and their differentiation into myofibroblasts,AZIN1 and JNK1 were identified as two target genes of miR-433. Decreased level of azin1 activated TGF-beta1 while down-regulation of JNK1 resulted in activation of ERK and p38 kinase leading to smad3 activation and ultimately cardiac fibrosis."
RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-433
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
immunofluorescence; PCR; etc.
Target
AZIN1;JNK1
Pathway
MAPK SIGNALING PATHWAY
PubMed ID
Title
Crucial Role of miR-433 in Regulating Cardiac Fibrosis
Year
2016
Function
"Forced expression of miR-433 in neonatal rat cardiac fibroblasts increased proliferation and their differentiation into myofibroblasts,AZIN1 and JNK1 were identified as two target genes of miR-433. Decreased level of azin1 activated TGF-beta1 while down-regulation of JNK1 resulted in activation of ERK and p38 kinase leading to smad4 activation and ultimately cardiac fibrosis."